Asthma

Definition

Chronic airway inflammation leading to bronchospasm + recurrent episodes of wheezing, breathlessness, chest tightness and coughing + triggered by cold weather, dust, fur or exercise.

*asthma is a reversible airway obstruction

Clinical Features

History

  • Current symptoms
  • Pattern of symptoms
  • Precipitating factors
  • Present treatment
  • Previous hospital admission
  • Typical exacerbations
  • Home/ school environment Impact on life style
  • History of atopy
  • Response to prior treatment
  • Prolonged URTI symptoms
  • Family history

Physical Examination

  • Signs of chronic illness
  • Harrison’s sulci
  • Hyperinflated chest
  • Eczema / dry skin
  • Hypertrophied turbinates
  • Signs in acute exacerbation
  • Tachypnoea
  • Wheeze, rhonchi
  • Hyperinflated chest
  • Accessory muscles
  • Cyanosis
  • Drowsiness
  • Tachycardia

Children less than 5 years old

To diagnose asthma

  • Largely based on symptoms pattern + clinical history + physical findings
  • Predictive factor: +ve family history & atopy
  • It is difficult to diagnose asthma in this age group because wheeze and cough are common in children without asthma
Table: Probability of Asthma

Features suggestive of asthma

  1. Cough
    • Recurrent/persistent non-productive cough, worsens at night, accompanied by wheeze or breathlessness. Cough in the absence of respiratory infections, usually with laughing, crying or exposure to tobacco smoke.
  2. Wheezing
    • Recurrent wheezing during sleep or with triggers such as activity, laughing, crying or exposure to tobacco smoke or air pollution
  3. Shortness of breath
    • Difficult or heavy breathing or shortness of breath occurring with exercise, laughing or playing.
  4. Reduced activity
  5. Past/family history
    • Allergic disease or asthma in first degree relative.
  6. Therapeutic trial with moderate dose inhaled steroids
    • Clinical improvement in 2-4 weeks of controller treatment and worsening when treatment is stopped.

Management

Treatment of Asthma for Children <5 y/o

Step 1

Controller: nil
Reliever: SABA PRN
For children with: Infrequent viral wheezing and no/few interval symptoms

Step 2

Controller: Daily low dose ICS (preferred), LTRA
Reliever: SABA PRN
For children with: Symptoms consistent with asthma, not well-controlled asthma, ≥3 exacerbations per year

Step 3

Controller: Double low dose ICS (preferred), low dose ICS + LTRA
Reliever: SABA PRN
For children with: Asthma diagnosis, not well-controlled asthma on low dose ICS

Step 4

Controller: Continue controller and refer to specialist (preferred), add LTRA, increase ICS freq.
Reliever: SABA PRN
For children with: Poorly controlled asthma on double ICS

Summary

Table: Treatment of Asthma for Children <5 y/o